Antiglomerular basement membrane glomerulonephritis following D-penicillamine-associated nephrotic syndrome.

Antiglomerular basement membrane (anti-GBM) glomerulonephritis (GN) is rare and is characterized by rapidly progressive GN with IgG linear deposits along the GBM in immunofluorescence study and circulating anti-GBM antibodies. This form of GN usually occurs without previous renal disease, but some cases of membranous GN have been reported with secondary development of antiGBM disease [1,2]. Administration of drugs such as D-penicillamine, which are useful for the treatment of rhumatoid arthritis, can be complicated by glomerular disease, more Fig. 2. Linear diffuse IgG deposits on the residual GBM precisely membranous GN, but also minimal-change (Immunofluorescence, ×1000). GN, and crescentic GN [3–5]. Mechanisms for the